- Author: H. S. Patel, A. R. Silver, T. Levine, G. Williams, J. M. Northover
- Published: Aug 20, 2010
- Pages: 1716-1721
- DOI: 10.1002/bjs.7218
Abstract
Background:
Immunosuppression is a known risk factor for anal human
papillomavirus (HPV) disease, including anal squamous cell carcinoma.
Additional risk factors for HPV‐related disease have not
been studied in the renal transplant population. The demographics
of anal HPV and associated risk factors were investigated
in this population.
Methods:
Anal cytology and polymerase chain reaction were used to
assess anal HPV disease in a cohort of transplant recipients at the
Royal London Hospital. Risk factors associated with
increased immunosuppression and HPV exposure were collated to determine
any association with anal disease.
Results:
Anal dysplasia was associated with anal oncogenic HPV infection (P < 0·001), duration of immunosuppression (P = 0·050), previous genital warts (P = 0·018) and receptive anal intercourse (P = 0·013).
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